Maculopathy: Causes and Symptoms

Maculopathy and its causes

Maculopathy, or macular degeneration, is a disease related to the central part of the retina, called macula.

Maculopathy is characterized by a progressive loss of central vision, usually bilateral, that greatly impairs vision functions.

In any case, degenerative maculopathy never leads to complete blindness since lateral vision is usually preserved till the terminal phases of retinal maculopathy

Senile maculopathy, or macular degeneration related to the patient’s age, is the most frequent form of maculopathy, that affects 25 to 30 millions of people in the western world.
Other maculopathy forms are:

  • myopia maculopathy,
  • diabetic maculopathy,
  • exudative maculopathy after venous thrombosis of the retina.
  • cellophane maculopathy or macular Pucker

Maculopathy Symptoms

Maculopathy or macular degeneration is painless. It could happen that patients don’t notice any vision problem, because the healthy eye compensates. First symptoms usually are:

  • Image distortion (metamorphopsis), where objects appear deformed and/or smaller.
  • When the affected part is the macula (fovea) central portion, a central spot appear, where patients cannot see: for example, while looking at someone’s face, patients will be able to see the ears but not facial expressions, eyes or mouth; or, it would be possible to see a clock, but not the time depicted.
    This evolution can happen very quickly or over a longer period of time (months).

This is why it is best to often do the Amsler Test to monitor the vision status.
Such symptoms could be a warning sign and should end in an appointment to the ophthalmologist, the sooner the better.

Age related macular degeneration (AMD)

Senile maculopathy, or macular degeneration related to the patient’s age, is the most common maculopathy. There are two kinds: dry maculopathy and wet maculopathy.

Dry Macular Degeneration

Dry maculopathy is the most frequent one. In 90% of maculopathies are dry ones: the retina gets thinner because vision cells stop working and disappear; for this form, also known as atrophic maculopathy, laser therapy has proven to be ineffective.

Nutritive factors transport and waste elimination by the retinal pigmented epithelium (RPE) are slowed down: yellowish intraretinal deposits (drusen) or pigmented (dystrophy, focal pigment) appear.

There is usually a small vision impairment and only in a few cases have been experienced atrophied zones that look like retinal stretch marks and also involve the central part (fovea).

Wet Macular Degeneration

In case of exudative maculopathy, it is believed that a small nutritive factors supply to the retina could stimulate substances called vascular endothelial growth factors (or VEGF), that give the signal for the production of irregular vases that seep serum or bleed, stimulating the formation of a scar. Proliferation of new vases under the retina is called choroidal neovascularization or CNV.

In the 10% of cases, neovessels grow in the retina and then deepen into the choroid; in this case we speak of a retinal angiomatous proliferation or RAP.

A variation (experienced in 3-4% of cases) called polypoidal vasculopathy, fosters bleedings under the retina along with the lifting of the pigmented epithelium (PED) and is often bilateral: it has a good prognosis though. A portion of dry maculopathies can become exudative over time, so it is important to monitor its growth. Moreover, treatments that succeed in closing such vessels cannot block relapses.

In the last years there have been several news in terms of maculopathy diagnosis and cure.
Today there is an early diagnosis thanks to the OCT exam, treatment to prevent maculopathy as well as a genetic test able to spot who’s at risk of maculopathy.
Maculopathy therapy uses modern medications and laser treatments that are constantly evolving. Dr. Badalà performs such treatments to cure maculopathy in Milan and Catania.

Macular pucker

Macular pucker is a form of maculopathy linked to the patient’s age and it is characterized by a growth of a thin membrane on the inner side of the retina that could cause over time a distorted image perception.

Diagnosis is made with an accurate retina examination and an exam called OCT.
Usually it is not necessary to intervene to cure cellophane maculopathy; if the disease grows, it is called macular pucker. In these cases, the membrane becomes thicker distort the retina. Maculopathy cure will then be vitrectomy.

Amsler Test or Maculopathy Test

This is a very simple test that everyone can do in his/her home at any given time. The goal of this test is to spot as early as possible the metamorphopsia, that is the most typical symptom of degenerative maculopathy or macular degeneration. When speaking of metamorphopsia, we mean the deformation, curvature, distortion of everything that is originally straight (lines, door jambs, stair steps,…)

Usually this is noticed better while reading: the patient sees distorted lines on the newspaper, curved, or broken. Unfortunately this symptom is not always noticed as early as it should be: it may happen that patients recognize the condition only when the healthy eye is covered.

The Amsler test (or grid) is very useful when there may be a maculopathy or if you want to monitor the evolution overtime of a degenerative maculopathy. Who should do the Amsler test? Anyone who is at risk of developing macular degenerations, such as:

  • people that are more than 50 years old
  • people with high degree myopia
  • people that have one eye that has previously been affected by the disease
  • people that discovered risks factor during a routine ophthalmologic exam, like the presence of drusen (especially soft ones) on the retina. Drusen are yellow agglomerates that appear under the retina and represent the difficulty of eliminate waste material.

Dr. Badalà performed important researches and worked in some of the most important maculopathy centers in the world like the Wills Eye Institute of Filadelfia and the Jules Stein Eye Institute in Los Angeles, and is involved today in clinical studies on new treatments for maculopathy in Milan and Catania.

Giuseppe Grasso, Catania

Votazione: Eccellente
After having consulted several doctors, last year I turned to Dr. Badalà because I felt a discomfort to the eye. At first sight Dr. Badalà realized that there was something wrong in my right eye and, after a thorough e... Keep on reading this reviewxamination and an OCT, he confirmed the presence of a hole in the retina (which no other doctor had seen before) and he suggested me a vitrectomy.

After consulting other doctors who, despite having confirmed the diagnosis, suggested me to wait, I decided to entrust Dr. Badalà, because he inspired me with confidence during the visit.

I had a vitrectomy under local anesthesia about five months ago. The surgery was good and my eyesight has improved and I no longer see distorted images.

The thing that struck me most is that at first I was so used to don’t  see well that I didn’t  realize it, so much so that I had turned to Dr. Badalà just for a burning sensation to the eye. Thanks to the professionalism and accuracy of Dr. Badalà today I realize I see much better.
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